​​Top-Down Fabrication of Shape-Controlled, Monodisperse Nanoparticles for Biomedical Applications​

Our Chief Scientist Professor Ge Haixiong has been invited to publish a review article titled Top-down fabrication of shape-controlled monodisperse nanoparticles for biomedical applications in the internationally renowned pharmaceutical journal Advanced Drug Delivery Reviews. This research was completed in collaboration with Professor Hu Yong from the School of Modern Engineering and Applied Sciences at Nanjing University. The paper also received significant support from another Chief Scientist of our company Professor Li Wendi and his team at the University of Hong Kong.

The paper builds upon the long-term micro and nano fabrication research conducted by Professor Ge Haixiong and Professor Li Wendi combined with Professor Hu Yongs extensive work in biomedical fields. It proposes the use of top-down methods to prepare nanoparticles with controllable shape size and composition for applications in drug targeting drug and gene delivery novel cancer therapies and biomedical imaging.

Nanoparticles are widely used in biomedical fields such as drug release and delivery biosensing and disease diagnosis and treatment. Traditional bottom-up methods including self-assembly emulsion and precipitation-based chemical synthesis are currently the primary means of preparing nanoparticles in biomedicine. However these bottom-up approaches face significant challenges in controlling particle shape and size. Yet the shape and size of nanoparticles play a decisive role in their applications making this a major bottleneck for bottom-up methods.

In contrast to bottom-up methods top-down approaches represented by photolithography and nanoimprint lithography utilize precisely controlled and defined structures such as masks or molds or energy forms such as light or electron beams to create nanoscale patterns with specific and uniform shapes and sizes. These nanoscale patterns are then combined with microfabrication techniques like etching and coating to produce nanoparticles. This process enables the creation of nanoparticles with specific shapes uniform sizes and controllable composition allowing precise tuning of nanoparticle properties to meet the requirements for biomedical applications.

This research was supported by the National Key R&D Program of China (2017YFA0205400), the National Natural Science Foundation of China (21474047, 51773089), and the Hong Kong Research Grants Council (27205515, 17246116).

We welcome interested industry partners to contact us for further collaboration in related fields.

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